Gun Ownership and Firearm-related Deaths

BACKGROUND: A variety of claims about possible associations between gun ownership rates, mental illness burden, and the risk of fi rearm-related deaths have been put forward. However, systematic data on this issue among various countries remain scant. Our objective was to assess whether the popular notion "guns make a nation safer" has any merits.METHODS: Data on gun ownership were obtained from the Small Arms Survey, and for fi rearm-related deaths from a European detailed mortality database (World Health Organization), the National Center for Health Statistics, and others. Crime rate was used as an indicator of safety of the nation and was obtained from the United Nations Surveys of Crime Trends. Age-standardized disability-adjusted life- year rates due to major depressive disorder per 100,000 inhabitants with data obtained from the World Health Organization database were used as a putative indicator for mental illness burden in a given country.RESULTS: Among the 27 developed countries, there was a significant positive correlation between guns per capita per country and the rate of fi rearm-related deaths ( r ¼ 0.80; P < .0001). In addition, there was a positive correlation (r ¼ 0.52; P ¼ .005) between mental illness burden in a country and fi rearm-related deaths. However, there was no significant correlation (P ¼ .10) between guns per capita per country and crime rate ( r ¼ .33), or between mental illness and crime rate ( r ¼ 0.32; P ¼ .11). In a linear regression model with fi rearm-related deaths as the dependent variable with gun ownership and mental illness as independent covariates, gun ownership was a significant predictor ( P < .0001) of fi rearm-related deaths, whereas mental illness was of borderline significance ( P ¼ .05) only.CONCLUSION: The number of guns per capita per country was a strong and independent predictor of fi rearm-related death in a given country, whereas the predictive power of the mental illness burden was of borderline significance in a multivariable model. Regardless of exact cause and effect, however, the current study debunks the widely quoted hypothesis that guns make a nation safer

Overlap properties and adsorption transition of two Hamiltonian paths

We consider a model of two (fully) compact polymer chains, coupled through an attractive interaction. These compact chains are represented by Hamiltonian paths (HP), and the coupling favors the existence of common bonds between the chains. Using a ($n=0$ component) spin representation for these paths, we show the existence of a phase transition for strong coupling (i.e. at low temperature) towards a ``frozen'' phase where one chain is completely adsorbed onto the other. By performing a Legendre transform, we obtain the probability distribution of overlaps. The fraction of common bonds between two HP, i.e. their overlap $q$, has both lower ($q_m$) and upper ($q_M$) bounds. This means in particuliar that two HP with overlap greater than $q_M$ coincide. These results may be of interest in (bio)polymers and in optimization problems.Comment: 13 pages, 2 figure

Wormhole Effect in a Strong Topological Insulator

An infinitely thin solenoid carrying magnetic flux Phi (a `Dirac string') inserted into an ordinary band insulator has no significant effect on the spectrum of electrons. In a strong topological insulator, remarkably, such a solenoid carries protected gapless one-dimensional fermionic modes when Phi=hc/2e. These modes are spin-filtered and represent a distinct bulk manifestation of the topologically non-trivial insulator. We establish this `wormhole' effect by both general qualitative considerations and by numerical calculations within a minimal lattice model. We also discuss the possibility of experimental observation of a closely related effect in artificially engineered nanostructures.Comment: 4 pages, 3 figures. For related work and info visit http://www.physics.ubc.ca/~fran

Connexin 40 promoter-based enrichment of embryonic stem cell-derived cardiovascular progenitor cells

Background: Pluripotent embryonic stem (ES) cells that can differentiate into functional cardiomyocytes as well as vascular cells in cell culture may open the door to cardiovascular cell transplantation. However, the percentage of ES cells in embryoid bodies (EBs) which spontaneously undergo cardiovascular differentiation is low (< 10%), making strategies for their specific labeling and purification indispensable. Methods: The human connexin 40 (Cx40) promoter was isolated and cloned in the vector pEGFP. The specificity of the construct was initially assessed in Xenopus embryos injected with Cx40-EGFP plasmid DNA. Stable Cx40-EGFP ES cell clones were differentiated and fluorescent cells were enriched manually as well as via fluorescence-activated cell sorting. Characterization of these cells was performed with respect to spontaneous beating as well as via RT-PCRs and immunofluorescent stainings. Results: Cx40-EGFP reporter plasmid injection led to EGFP fluorescence specifically in the abdominal aorta of frog tadpoles. After crude manual enrichment of highly Cx40-EGFP- positive EBs, the appearance of cardiac and vascular structures was increased approximately 3-fold. Immuno fluorescent stainings showed EGFP expression exclusively in vascular-like structures simultaneously expressing von Willebrand factor and in formerly beating areas expressing alpha-actinin. Cx40-EGFP-expressing EBs revealed significantly higher numbers of beating cardiomyocytes and vascular-like structures. Semiquantitative RT-PCRs confirmed an enhanced cardiovascular differentiation as shown for the cardiac markers Nkx2.5 and MLC2v, as well as the endothelial marker vascular endothelial cadherin. Conclusions: Our work shows the feasibility of specific labeling and purification of cardiovascular progenitor cells from differentiating EBs based on the Cx40 promoter. We provide proof of principle that the deleted CD4 (Delta CD4) surface marker-based method for magnetic cell sorting developed by our group will be ideally suitable for transference to this promoter. Copyright (c) 2008 S. Karger AG, Basel

Vortices, zero modes and fractionalization in bilayer-graphene exciton condensate

A real-space formulation is given for the recently discussed exciton condensate in a symmetrically biased graphene bilayer. We show that in the continuum limit an oddly-quantized vortex in this condensate binds exactly one zero mode per valley index of the bilayer. In the full lattice model the zero modes are split slightly due to intervalley mixing. We support these results by an exact numerical diagonalization of the lattice Hamiltonian. We also discuss the effect of the zero modes on the charge content of these vortices and deduce some of their interesting properties.Comment: (v2) A typo in Fig. 1 and a slight error in Eq. (4) corrected; all the main results and conclusions remain unchange

Representational momentum in the motor system?

PURPOSE: If presented with a moving object which suddenly disappears observers usually misjudge the object's last seen position as being further forward along the path of motion. This effect, called representational momentum, can also be seen in objects that change size or shape. It has been argued that the effect is due to perceptual anticipation. We tested whether a similar effect is present in the motor system. METHODS: Using stereo computer graphics we presented cubes of different sizes on a CRT monitor. In each trial three cubes were successively presented for 200 msec with increasing or decreasing size (steps of 1 cm width difference). Ten participants either compared the last cube to a comparison cube (perceptual task) or grasped the cube using a virtual haptic setup (motor task). The setup consisted of two robot arms (Phantom TM) attached to index finger and thumb. The robot arms were controlled to create forces equivalent to the forces created by real objects. The CRT monitor was viewed via a mirror such that the visual position of the cubes matched the position of the virtual haptic objects. RESULTS: In the motor task participants opened their fingers by 1.1+/-0.4 mm wider if they grasped a cube that was preceded by smaller cubes than if they grasped a cube that was preceded by larger cubes. This is the well-known representational momentum effect. In the perceptual task the effect was reversed (-2.2+/-0.4 mm). The effects correlated between observers (r=.71, p=.02). CONCLUSIONS: It seems that a representational momentum occurs also in grasping tasks. The correlation between observers suggests that the motor effect is related to the perceptual effect. However, our perceptual task showed a reversed effect. Reasons for this discrepancy will be discussed

Theory of quasiparticle interference on the surface of a strong topological insulator

Electrons on the surface of a strong topological insulator, such as Bi2Te3 or Bi1-xSnx, form a topologically protected helical liquid whose excitation spectrum contains an odd number of massless Dirac fermions. A theoretical survey and classification is given of the universal features, observable by the ordinary and spin-polarized scanning tunneling spectroscopy, in the interference patterns resulting from the quasiparticle scattering by magnetic and non-magnetic impurities in such a helical liquid. Our results confirm the absence of backscattering from non-magnetic impurities observed in recent experiments and predict new interference features, uniquely characteristic of the helical liquid, when the scatterers are magnetic.Comment: 4 pages, 2 figures, 1 table. Version to appear in PRB/RC; Typos correcte